PDBe 4dnk

X-ray diffraction
2.2Å resolution

Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) from homo sapiens at 2.20 A resolution.

Released:
Source organism: Homo sapiens
Entry authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
14-3-3 protein beta/alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 247 amino acids
Theoretical weight: 28.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31946 (Residues: 1-246; Coverage: 100%)
Gene name: YWHAB
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 52.144Å b: 122.848Å c: 55.256Å
α: 90° β: 113.98° γ: 90°
R-values:
R R work R free
0.194 0.192 0.226
Expression system: Escherichia coli