PDBe 4dmu

X-ray diffraction
2.8Å resolution

Crystal structure of the von Willebrand factor A3 domain in complex with a collagen III derived triple-helical peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
von Willebrand factor Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 192 amino acids
Theoretical weight: 20.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04275 (Residues: 1683-1874; Coverage: 7%)
Gene names: F8VWF, VWF
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain
Collagen III derived triple-helical peptide Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 87 amino acids
Theoretical weight: 7.74 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6
Unit cell:
a: 187.614Å b: 187.614Å c: 89.373Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.253
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided