PDBe 4djs

X-ray diffraction
3.03Å resolution

Structure of beta-catenin in complex with a stapled peptide inhibitor

Released:
Source organism: Homo sapiens
Primary publication:
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin.
Proc. Natl. Acad. Sci. U.S.A. 109 17942-7 (2012)
PMID: 23071338

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin beta-1 Chain: A
Molecule details ›
Chain: A
Length: 518 amino acids
Theoretical weight: 56.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35222 (Residues: 148-665; Coverage: 66%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
stapled peptide RRWPQ(MK8)ILD(MK8)HVRRVWR Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 2.33 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 63.06Å b: 74.808Å c: 135.714Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.266 0.263 0.291
Expression systems:
  • Escherichia coli
  • Not provided