› 4di3

X-ray diffraction
3.05Å resolution

Crystal structure of a 2:1 complex of Treponema pallidum TatP(T) (Tp0957) bound to TatT (Tp0956)

Released:
DOI: 10.2210/pdb4di3/pdb
PDB entry 4di3 coloured by chain, front view.
PDB entry 4di3 coloured by chain, side view.
PDB entry 4di3 coloured by chain, top view.
Source organism: Treponema pallidum subsp. pallidum str. Nichols
Primary publication:
Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).
Brautigam CA, Deka RK, Schuck P, Tomchick DR, Norgard MV
J Mol Biol 420 70-86 (2012)
PMID: 22504226

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131396 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tp33 protein Chains: D, E
Molecule details ›
Chains: D, E
Length: 324 amino acids
Theoretical weight: 36.28 KDa
Source organism: Treponema pallidum subsp. pallidum str. Nichols
Expression system: Escherichia coli
UniProt:
  • Canonical: O83923 (Residues: 21-342; Coverage: 94%)
Gene name: TP_0957
Sequence domains: Bacterial extracellular solute-binding protein, family 7
Structure domains: Bacterial extracellular solute-binding protein, family 7
TatT (Tp0956) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 301 amino acids
Theoretical weight: 33.72 KDa
Source organism: Treponema pallidum subsp. pallidum str. Nichols
Expression system: Escherichia coli
UniProt:
  • Canonical: O83922 (Residues: 23-323; Coverage: 93%)
Gene name: TP_0956
Sequence domains: TRAP transporter T-component
Structure domains: TRAP transporter T-component

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4122
Unit cell:
a: 148.934Å b: 148.934Å c: 212.805Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.263
Expression system: Escherichia coli

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Citations

4 review citations

Syphilis.
Peeling et al. (2017)
3 more

1 mention without citation

Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).
Brautigam et al. (2012)