PDBe 4dgl

X-ray diffraction
3Å resolution

Crystal Structure of the CK2 Tetrameric Holoenzyme

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Casein kinase II subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P67870 (Residues: 1-215; Coverage: 100%)
Gene names: CK2N, CSNK2B, G5A
Sequence domains: Casein kinase II regulatory subunit
Structure domains:
Casein kinase II subunit alpha Chains: C, D
Molecule details ›
Chains: C, D
Length: 335 amino acids
Theoretical weight: 40.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
  • Best match: P68400-2 (Residues: 1-199)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P63
Unit cell:
a: 175.652Å b: 175.652Å c: 96.26Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.222
Expression system: Escherichia coli