PDBe 4dch

X-ray diffraction
1.79Å resolution

Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations

Released:

Function and Biology Details

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucokinase Chain: A
Molecule details ›
Chain: A
Length: 473 amino acids
Theoretical weight: 53.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 1-465; Coverage: 100%)
Gene name: GCK
Sequence domains:
Structure domains: Hexokinase; domain 1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 49.917Å b: 85.794Å c: 72.939Å
α: 90° β: 104.4° γ: 90°
R-values:
R R work R free
0.2 0.198 0.231
Expression system: Escherichia coli