Function and Biology Details
Reaction catalysed:
ATP + H(2)O + vitamin B12-[cobalamin-binding protein](Side 1) = ADP + phosphate + vitamin B12(Side 2) + [cobalamin-binding protein](Side 1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- P-loop containing nucleoside triphosphate hydrolase
- ABC transporter-like, ATP-binding domain
- ABC transporter, permease protein, BtuC-like
- ABC transporter, BtuC-like
- ABC transporter periplasmic binding domain
- ABC transporter-like, conserved site
- AAA+ ATPase domain
- ABC transporter, vitamin B12, BtuD
2 more domains
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
Cobalamin ABC transporter complex (preferred)
PDBe Complex ID:
PDB-CPX-139093 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Vitamin B12 import system permease protein BtuC
Molecule details ›
Chains: A, B, F, G
Length: 349 amino acids
Theoretical weight: 37.65 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
Sequence domains: FecCD transport family
Structure domains: ABC transporter involved in vitamin B12 uptake, BtuC
Length: 349 amino acids
Theoretical weight: 37.65 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
- Canonical:
P06609 (Residues: 1-326; Coverage: 100%)
Sequence domains: FecCD transport family
Structure domains: ABC transporter involved in vitamin B12 uptake, BtuC
Vitamin B12 import ATP-binding protein BtuD
Molecule details ›
Chains: C, D, H, I
Length: 249 amino acids
Theoretical weight: 27.1 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Length: 249 amino acids
Theoretical weight: 27.1 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
- Canonical: P06611 (Residues: 1-249; Coverage: 100%)
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Vitamin B12-binding protein
Molecule details ›
Chains: E, J
Length: 255 amino acids
Theoretical weight: 28.24 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
Sequence domains: Periplasmic binding protein
Structure domains: Nitrogenase molybdenum iron protein domain
Length: 255 amino acids
Theoretical weight: 28.24 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
- Canonical: P37028 (Residues: 22-266; Coverage: 100%)
Sequence domains: Periplasmic binding protein
Structure domains: Nitrogenase molybdenum iron protein domain
