PDBe 4d0z

X-ray diffraction
2.2Å resolution

GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 and manganese (Higher resolution dataset)

Released:

Function and Biology Details

Reaction catalysed:
UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Polypeptide N-acetylgalactosaminyltransferase 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 571 amino acids
Theoretical weight: 64.82 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q10471 (Residues: 1-571; Coverage: 100%)
Gene name: GALNT2
Sequence domains:
Structure domains:
Cysteine-rich, angiogenic inducer, 61, isoform CRA_a Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 6 amino acids
Theoretical weight: 549 Da
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q6FI18 (Residues: 24-29; Coverage: 1%)
Gene names: CYR61, hCG_23652

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 116.485Å b: 121.143Å c: 249.387Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.234
Expression system: Komagataella pastoris