PDBe 4cia

X-ray diffraction
1.98Å resolution

Crystal structure of cathepsin A, complexed with compound 1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysosomal protective protein Chain: A
Molecule details ›
Chain: A
Length: 455 amino acids
Theoretical weight: 51.83 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10619 (Residues: 29-480; Coverage: 100%)
Gene names: CTSA, PPGB
Sequence domains: Serine carboxypeptidase
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 90.106Å b: 101.295Å c: 48.077Å
α: 90° β: 101.91° γ: 90°
R-values:
R R work R free
0.173 0.17 0.232
Expression system: Spodoptera frugiperda