PDBe 4c7b

X-ray diffraction
2.1Å resolution

Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 31.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NTG7 (Residues: 117-399; Coverage: 71%)
Gene names: SIR2L3, SIRT3
Sequence domains: Sir2 family
Structure domains:
PEPTIDE Chain: B
Molecule details ›
Chain: B
Length: 4 amino acids
Theoretical weight: 770 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: R32
Unit cell:
a: 114.82Å b: 114.82Å c: 123.75Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.18 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided