PDBe 4c62

X-ray diffraction
2.75Å resolution

Inhibitors of Jak2 Kinase domain


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 35.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: O60674 (Residues: 835-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2
Unit cell:
a: 44.507Å b: 126.889Å c: 135.875Å
α: 90° β: 97.53° γ: 90°
R R work R free
0.199 0.196 0.246
Expression system: Escherichia coli BL21