PDBe 4c3f

X-ray diffraction
1.72Å resolution

Structure of Lck in complex with a compound discovered by Virtual Fragment Linking

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 30.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P06239 (Residues: 237-501; Coverage: 52%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P212121
Unit cell:
a: 58.088Å b: 44.596Å c: 120.254Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.22
Expression system: Spodoptera frugiperda