PDBe 4c2k

X-ray diffraction
2Å resolution

Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
3-ketoacyl-CoA thiolase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 417 amino acids
Theoretical weight: 44.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P42765 (Residues: 1-397; Coverage: 100%)
Gene name: ACAA2
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 54.73Å b: 196.77Å c: 79.65Å
α: 90° β: 103.78° γ: 90°
R R work R free
0.197 0.195 0.229
Expression system: Escherichia coli BL21(DE3)