PDBe 4bw5

X-ray diffraction
3.2Å resolution

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1)


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Potassium channel subfamily K member 10 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 282 amino acids
Theoretical weight: 31.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P57789 (Residues: 62-335; Coverage: 51%)
Gene names: KCNK10, TREK2
Sequence domains: Ion channel
Structure domains: Helix Hairpins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 87.83Å b: 96.96Å c: 103.7Å
α: 90° β: 92.58° γ: 90°
R R work R free
0.238 0.237 0.254
Expression system: Spodoptera frugiperda