PDBe 4bvc

X-ray diffraction
1.6Å resolution

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Released:
Source organism: Homo sapiens
Entry authors: Sandmark J, Althage M, Andersson GMK, Antonsson T, Blaho S, Bodin C, Bostrom J, Chen Y, Dahlen A, Eriksson PO, Evertsson E, Fex T, Fjellstrom O, Gustafsson D, Hallberg C, Hicks R, Jarkvist E, Johansson C, Kalies I, Kang D, Svalstedt Karlsson B, Kartberg F, Legnehed A, Lindqvist AM, Martinsson SA, Moberg A, Petersson AU, Ridderstrom M, Thelin A, Tigerstrom A, Vinblad J, Xu B, Knecht W

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein(a) Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.16 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08519 (Residues: 4123-4201; Coverage: 2%)
Gene name: LPA
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+
Spacegroup: P212121
Unit cell:
a: 24.55Å b: 45.69Å c: 55.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.157 0.194
Expression system: Komagataella pastoris