PDBe 4bv5

X-ray diffraction
2.1Å resolution

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Source organism: Homo sapiens
Entry authors: Sandmark J, Althage M, Andersson GMK, Antonsson T, Blaho S, Bodin C, Bostrom J, Chen Y, Dahlen A, Eriksson PO, Evertsson E, Fex T, Fjellstrom O, Gustafsson D, Hallberg C, Hicks R, Jarkvist E, Johansson C, Kalies I, Kang D, Svalstedt Karlsson B, Kartberg F, Legnehed A, Lindqvist AM, Martinsson SA, Moberg A, Petersson AU, Ridderstrom M, Thelin A, Tigerstrom A, Vinblad J, Xu B, Knecht W

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Apolipoprotein(a) Chains: A, B
Molecule details ›
Chains: A, B
Length: 79 amino acids
Theoretical weight: 9.16 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: NEW P08519 (Residues: 4123-4201; Coverage: 2%)
Gene name: LPA
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+
Spacegroup: P21
Unit cell:
a: 24.41Å b: 45.25Å c: 56.1Å
α: 90° β: 90.67° γ: 90°
R R work R free
0.192 0.19 0.23
Expression system: Komagataella pastoris