PDBe 4bqa

X-ray diffraction
2.5Å resolution

Crystal structure of the ETS domain of human ETS2 in complex with DNA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Protein C-ets-2 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 142 amino acids
Theoretical weight: 16.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15036 (Residues: 325-464; Coverage: 30%)
Gene name: ETS2
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3' Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 10 nucleotides
Theoretical weight: 3.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3' Chains: C, F, I
Molecule details ›
Chains: C, F, I
Length: 10 nucleotides
Theoretical weight: 3 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 36.674Å b: 96.964Å c: 83.803Å
α: 90° β: 97.06° γ: 90°
R-values:
R R work R free
0.235 0.234 0.255
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided