PDBe 4bn5

X-ray diffraction
3.25Å resolution

Structure of human SIRT3 in complex with SRT1720 inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 281 amino acids
Theoretical weight: 31.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NTG7 (Residues: 119-399; Coverage: 70%)
Gene names: SIR2L3, SIRT3
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 227.82Å b: 246.06Å c: 127.34Å
α: 90° β: 123.88° γ: 90°
R-values:
R R work R free
0.211 0.208 0.265
Expression system: Escherichia coli BL21(DE3)