PDBe 4bgk

X-ray diffraction
2.18Å resolution

Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with (3-(Trimethylammonio)propyl)phosphinate


Function and Biology Details

Reaction catalysed:
4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO(2) 

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Gamma-butyrobetaine dioxygenase Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 44.77 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
  • Canonical: O75936 (Residues: 1-387; Coverage: 100%)
Gene names: BBH, BBOX, BBOX1
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: R32
Unit cell:
a: 107.72Å b: 107.72Å c: 204.71Å
α: 90° β: 90° γ: 120°
R R work R free
0.148 0.146 0.194
Expression system: Saccharomyces cerevisiae