PDBe 4bd3

Solution NMR

Phf19 links methylated lysine 36 of histone H3 to regulation of Polycomb activity

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PHD finger protein 19 Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: NEW Q5T6S3 (Residues: 38-95; Coverage: 10%)
Gene names: PCL3, PHF19
Sequence domains: Jumonji domain-containing protein 2A Tudor domain
Structure domains: SH3 type barrels.
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P68431 (Residues: 32-42; Coverage: 8%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: ARIA
Chemical shifts: BMR18764  
Expression systems:
  • Escherichia coli BL21
  • Not provided