PDBe 4azr

X-ray diffraction
2.95Å resolution

Human epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid anandamide

Released:
Source organism: Homo sapiens
Primary publication:
Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.
Acta Crystallogr. D Biol. Crystallogr. 70 290-8 (2014)
PMID: 24531463

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 15.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01469 (Residues: 1-135; Coverage: 100%)
Gene name: FABP5
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 66.12Å b: 115.15Å c: 108.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.219 0.268
Expression system: Escherichia coli BL21(DE3)