PDBe 4azf

X-ray diffraction
2.55Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity tyrosine-phosphorylation-regulated kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 417 amino acids
Theoretical weight: 48.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92630 (Residues: 146-540; Coverage: 66%)
Gene name: DYRK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P42212
Unit cell:
a: 83.461Å b: 83.461Å c: 148.534Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.255
Expression system: Escherichia coli BL21(DE3)