PDBe 4az3

X-ray diffraction
2.04Å resolution

crystal structure of cathepsin a, complexed with 15a

Released:

Function and Biology Details

Reaction catalysed:
Release of a C-terminal amino acid with broad specificity.
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lysosomal protective protein 32 kDa chain Chain: A
Molecule details ›
Chain: A
Length: 300 amino acids
Theoretical weight: 33.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10619 (Residues: 29-326; Coverage: 66%)
Gene names: CTSA, PPGB
Structure domains: Rossmann fold
Lysosomal protective protein 20 kDa chain Chain: B
Molecule details ›
Chain: B
Length: 155 amino acids
Theoretical weight: 18.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10619 (Residues: 327-480; Coverage: 34%)
Gene names: CTSA, PPGB
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 90.59Å b: 102.8Å c: 48.39Å
α: 90° β: 101.87° γ: 90°
R-values:
R R work R free
0.188 0.188 0.215
Expression system: Spodoptera frugiperda