PDBe 4ay9

X-ray diffraction
2.5Å resolution

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Follitropin subunit beta Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 111 amino acids
Theoretical weight: 12.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01225 (Residues: 19-129; Coverage: 100%)
Gene name: FSHB
Structure domains: Cystine-knot cytokines
Follicle-stimulating hormone receptor Chains: X, Y, Z
Molecule details ›
Chains: X, Y, Z
Length: 350 amino acids
Theoretical weight: 40.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23945 (Residues: 17-366; Coverage: 52%)
Gene names: FSHR, LGR1
Sequence domains:
Structure domains: Ribonuclease Inhibitor
Glycoprotein hormones alpha chain Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 92 amino acids
Theoretical weight: 10.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01215 (Residues: 25-116; Coverage: 100%)
Gene name: CGA
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P1
Unit cell:
a: 70.716Å b: 95.478Å c: 95.675Å
α: 60.3° β: 80.02° γ: 75.35°
R-values:
R R work R free
0.237 0.235 0.269
Expression system: Homo sapiens