PDBe 4aqh

X-ray diffraction
2.4Å resolution

Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 383 amino acids
Theoretical weight: 43.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P31
Unit cell:
a: 119.399Å b: 119.399Å c: 99.691Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.159 0.157 0.181
Expression system: Escherichia coli BL21(DE3)