PDBe 4anp

X-ray diffraction
2.11Å resolution

Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone


Function and Biology Details

Reaction catalysed:
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Phenylalanine-4-hydroxylase Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 37.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P00439 (Residues: 104-427; Coverage: 72%)
Gene name: PAH
Structure domains: Aromatic amino acid hydroxylase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER
Spacegroup: C2221
Unit cell:
a: 66.283Å b: 107.511Å c: 124.55Å
α: 90° β: 90° γ: 90°
R R work R free
0.205 0.204 0.237
Expression system: Escherichia coli BL21(DE3)