PDBe 4amt

X-ray diffraction
2.6Å resolution

Crystal structure at 2.6A of human prorenin

Released:
Source organism: Homo sapiens
Entry author: Zhou A

Function and Biology Details

Reaction catalysed:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 42.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00797 (Residues: 24-406; Coverage: 100%)
Gene name: REN
Sequence domains:
Structure domains: Acid Proteases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I41
Unit cell:
a: 141.32Å b: 141.32Å c: 75.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.266 0.264 0.3
Expression system: Homo sapiens