› 4a5r

X-ray diffraction
2.1Å resolution

Crystal structure of class A beta-lactamase from Bacillus licheniformis BS3 with tazobactam

Released:
DOI: 10.2210/pdb4a5r/pdb
PDB entry 4a5r coloured by chain, front view.
PDB entry 4a5r coloured by chain, side view.
PDB entry 4a5r coloured by chain, top view.
Source organism: Bacillus licheniformis
Entry authors: Power P, Sauvage E, Herman R, Kerff F, Charlier P

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chains: A, B
Molecule details ›
Chains: A, B
Length: 265 amino acids
Theoretical weight: 29.51 KDa
Source organism: Bacillus licheniformis
UniProt:
  • Canonical: P94458 (Residues: 1-265; Coverage: 100%)
Gene name: bla
Sequence domains:
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

4 bound ligands:
Ligand TBE 2 x TBE
Ligand CIT 1 x CIT
Ligand PGE 1 x PGE
Ligand CO2 2 x CO2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 46.955Å b: 103.55Å c: 63.732Å
α: 90° β: 94.77° γ: 90°
R-values:
R R work R free
0.185 0.182 0.233

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