PDBe 4a55

X-ray diffraction
3.5Å resolution

Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 279 amino acids
Theoretical weight: 33.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P27986 (Residues: 322-600; Coverage: 39%)
Gene names: GRB1, PIK3R1
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2, DIAMOND BEAMLINE I03
Spacegroup: I222
Unit cell:
a: 136.092Å b: 147.184Å c: 226.478Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.228
Expression system: Spodoptera frugiperda