Function and Biology

PHD finger of human UHRF1 in complex with unmodified histone H3 N- terminal tail

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00628
Domain description: PHD-finger
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1
The deposited structure of PDB entry 3zvy contains 2 copies of Pfam domain PF00628 (PHD-finger) in E3 ubiquitin-protein ligase UHRF1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR019787
Domain description: Zinc finger, PHD-finger
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1
IPR001841
Domain description: Zinc finger, RING-type
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1
IPR001965
Domain description: Zinc finger, PHD-type
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1
IPR011011
Domain description: Zinc finger, FYVE/PHD-type
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1
IPR019786
Domain description: Zinc finger, PHD-type, conserved site
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1
IPR045134
Domain description: UHRF1/2-like
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1

Structure domain

CATH CATH domain
3.30.40.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Herpes Virus-1
Homology: Zinc/RING finger domain, C3HC4 (zinc finger)
Occurring in:
  1. E3 ubiquitin-protein ligase UHRF1
The deposited structure of PDB entry 3zvy contains 2 copies of CATH domain 3.30.40.10 (Herpes Virus-1) in E3 ubiquitin-protein ligase UHRF1. Showing 1 copy in chain B.