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Catalytic domain of human SHP2

X-ray diffraction
1.4Å resolution
PDB entry 3zm1 coloured by chain, front view.
PDB entry 3zm1 coloured by chain, side view.
PDB entry 3zm1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 11
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Multimeric state: monomeric
Accessible surface area: 12193.91 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170287

Macromolecules

Tyrosine-protein phosphatase non-receptor type 11
Chain: A
Length: 284 amino acids
Theoretical weight: 33.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06124 (Residues: 248-527; Coverage: 47%)
Gene names: PTP2C, PTPN11, SHPTP2
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 3zm1, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 3zm1, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 3zm1, assembly 1, top view.
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