Function and Biology

Crystal structure of MEK1 in complex with fragment 18

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

EC 2.7.12.2: Mitogen-activated protein kinase kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein.
Comments:
  • A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation.
  • It is required for activation of EC 2.7.11.24.
  • Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
Systematic name:
ATP:protein phosphotransferase (MAPKKK-activated)
Alternative Name(s):
  • MAP kinase kinase
  • MAP kinase kinase 4
  • MAP kinase kinase 7
  • MAP kinase or ERK kinase
  • MAP2K
  • MAPKK
  • MAPKK1
  • MEK
  • MEK1
  • MEK2
  • MKK
  • MKK2
  • MKK4
  • MKK6
  • MKK7
  • STK27

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
1 copy of Pfam domain PF00069 (Protein kinase domain) in Dual specificity mitogen-activated protein kinase kinase 1 in PDB 3zlx.

InterPro InterPro annotations
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1

Structure domain

CATH CATH domain
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Dual specificity mitogen-activated protein kinase kinase 1 in PDB 3zlx.