Structure analysis

Crystal structure of MEK1 in complex with fragment 18

X-ray diffraction
2.2Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14900 Å2
Buried surface area: 650 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 4 kcal/mol
Interface energy (ΔGint): 0 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 348 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02750 (Residues: 37-383; Coverage: 88%)
Gene names: MAP2K1, MEK1, PRKMK1
Pfam: Protein kinase domain
InterPro:
CATH: Transferase(Phosphotransferase) domain 1

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