PDBe 3zlw

X-ray diffraction
2.12Å resolution

Crystal structure of MEK1 in complex with fragment 3

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity mitogen-activated protein kinase kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 38.95 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02750 (Residues: 37-383; Coverage: 88%)
Gene names: MAP2K1, MEK1, PRKMK1
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P6122
Unit cell:
a: 77.059Å b: 77.059Å c: 221.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.196 0.248
Expression system: Spodoptera frugiperda