PDBe 3zlr

X-ray diffraction
2.03Å resolution

Crystal structure of Bcl-xL in complex with inhibitor (WEHI-539).

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 158 amino acids
Theoretical weight: 17.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 66%)
  • Best match: Q07817-2 (Residues: 1-125, 126-146)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX
Spacegroup: P4322
Unit cell:
a: 56.241Å b: 56.241Å c: 211.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.158 0.208
Expression system: Escherichia coli BL21