Structure analysis

Crystal structure of Bcl-xL in complex with inhibitor (Compound 3).

X-ray diffraction
2.288Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule


Assembly 1 (preferred)
Multimeric state: monomeric
Accessible surface area: 7300 Å2
Buried surface area: 2200 Å2
Dissociation area: 300 Å2
Dissociation energy (ΔGdiss): -12 kcal/mol
Dissociation entropy (TΔSdiss): 4 kcal/mol
Interface energy (ΔGint): -3 kcal/mol
Symmetry number: 1


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