PDBe 3zln

X-ray diffraction
2.29Å resolution

Crystal structure of Bcl-xL in complex with inhibitor (Compound 3).

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 20.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 73%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX
Spacegroup: P41212
Unit cell:
a: 65.911Å b: 65.911Å c: 115.072Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.246
Expression system: Escherichia coli BL21(DE3)