PDBe 3zko

Electron Microscopy
13.7Å resolution

The structure of ''breathing'' dengue virus.

Released:
Source organism: Dengue virus 2
Related structures: EMD-2296

Function and Biology Details

Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- [mRNA]. 
ATP + H(2)O = ADP + phosphate. 
NTP + H(2)O = NDP + phosphate. 
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala. 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). 
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA. 
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assemblies composition:
homo 180-mer (preferred)
homo trimer
homo 15-mer
homo 18-mer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope protein E Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 495 amino acids
Theoretical weight: 54.4 KDa
Source organism: Dengue virus 2
UniProt:
  • Canonical: P12823 (Residues: 281-775; Coverage: 15%)
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 13.7Å
Relevant EMDB volumes: EMD-2296