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Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d

X-ray diffraction
2.645Å resolution
PDB entry 3zdi coloured by chain, front view.
PDB entry 3zdi coloured by chain, side view.
PDB entry 3zdi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Axin-1 and Glycogen synthase kinase-3 beta
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Multimeric state: hetero dimer
Accessible surface area: 17705.2 Å2
Buried surface area: 1543.53 Å2
Dissociation area: 674.19 Å2
Dissociation energy (ΔGdiss): 6.47 kcal/mol
Dissociation entropy (TΔSdiss): 8.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127343

Macromolecules

Glycogen synthase kinase-3 beta
Chain: A
Length: 350 amino acids
Theoretical weight: 39.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49841 (Residues: 35-384; Coverage: 83%)
Gene name: GSK3B
Pfam: Protein kinase domain
InterPro:
CATH:
Glycogen synthase kinase-3 beta in PDB entry 3zdi, assembly 1, front view.
Glycogen synthase kinase-3 beta in PDB entry 3zdi, assembly 1, side view.
Glycogen synthase kinase-3 beta in PDB entry 3zdi, assembly 1, top view.
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Axin-1
Chain: B
Length: 18 amino acids
Theoretical weight: 2.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15169 (Residues: 383-400; Coverage: 2%)
Gene names: AXIN, AXIN1
Axin-1 in PDB entry 3zdi, assembly 1, front view.
Axin-1 in PDB entry 3zdi, assembly 1, side view.
Axin-1 in PDB entry 3zdi, assembly 1, top view.
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