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Crystal structure of PIP4KIIBETA complex with AMP

X-ray diffraction
2.15Å resolution
PDB entry 3x01 coloured by chain, front view.
PDB entry 3x01 coloured by chain, side view.
PDB entry 3x01 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
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Multimeric state: homo dimer
Accessible surface area: 30138.35 Å2
Buried surface area: 4474.78 Å2
Dissociation area: 1,299.21 Å2
Dissociation energy (ΔGdiss): 4.65 kcal/mol
Dissociation entropy (TΔSdiss): 13.69 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-160254

Macromolecules

Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Chains: A, B
Length: 393 amino acids
Theoretical weight: 44.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78356 (Residues: 31-416; Coverage: 93%)
Gene names: PIP4K2B, PIP5K2B
Pfam: Phosphatidylinositol-4-phosphate 5-Kinase
InterPro:
CATH:
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta in PDB entry 3x01, assembly 1, front view.
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta in PDB entry 3x01, assembly 1, side view.
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta in PDB entry 3x01, assembly 1, top view.
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