› 3wfv

X-ray diffraction
1.8Å resolution

HIV-1 CRF07 gp41

Released:
DOI: 10.2210/pdb3wfv/pdb
PDB entry 3wfv coloured by chain, front view.
PDB entry 3wfv coloured by chain, side view.
PDB entry 3wfv coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat.
Du J, Xue H, Ma J, Liu F, Zhou J, Shao Y, Qiao W, Liu X
Virology 446 86-94 (2013)
PMID: 24074570

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.75 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q994K2 (Residues: 542-577, 624-660; Coverage: 9%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: R32
Unit cell:
a: 46.92Å b: 46.92Å c: 185.051Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.258
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Oregano Oil and Its Principal Component, Carvacrol, Inhibit HIV-1 Fusion into Target Cells.
Mediouni et al. (2020)
2 more

4 mentions without citation

Insights into vaccine development for acquired immune deficiency syndrome from crystal structures of human immunodeficiency virus-1 gp41 and equine infectious anemia virus gp45.
Duan et al. (2015)
3 more