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Crystal structure of human beta-galactosidase in complex with NBT-DGJ

Source organism: Homo sapiens
Biochemical function: protein homodimerization activity
Biological process: response to Thyroglobulin triiodothyronine
Cellular component: ficolin-1-rich granule lumen

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EC 3.2.1.23: Beta-galactosidase

Reaction catalysed:
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides
Systematic name:
Beta-D-galactoside galactohydrolase
Alternative Name(s):
  • Beta-D-galactanase
  • Beta-D-lactosidase
  • Beta-lactosidase
  • Exo-(1->4)-beta-D-galactanase
  • Hydrolact
  • Lactase
  • Lactozym
  • Maxilact
  • Oryzatym
  • S 2107
  • Sumiklat
  • Trilactase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF21467
Domain description: Beta-galactosidase, galactose-binding domain
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3wf2 contains 4 copies of Pfam domain PF21467 (Beta-galactosidase, galactose-binding domain) in Beta-galactosidase. Showing 1 copy in chain A.

PF21317
Domain description: Beta-galactosidase, first all-beta domain
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3wf2 contains 4 copies of Pfam domain PF21317 (Beta-galactosidase, first all-beta domain) in Beta-galactosidase. Showing 1 copy in chain A.

PF01301
Domain description: Glycosyl hydrolases family 35
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3wf2 contains 4 copies of Pfam domain PF01301 (Glycosyl hydrolases family 35) in Beta-galactosidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001944
Domain description: Glycoside hydrolase, family 35
Occurring in:
  1. Beta-galactosidase
IPR025300
Domain description: Beta-galactosidase jelly roll domain
Occurring in:
  1. Beta-galactosidase
IPR008979
Domain description: Galactose-binding-like domain superfamily
Occurring in:
  1. Beta-galactosidase
IPR019801
Domain description: Glycoside hydrolase, family 35, conserved site
Occurring in:
  1. Beta-galactosidase
IPR031330
Domain description: Glycoside hydrolase 35, catalytic domain
Occurring in:
  1. Beta-galactosidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Beta-galactosidase
IPR026283
Domain description: Beta-galactosidase 1-like
Occurring in:
  1. Beta-galactosidase

Structure domains

CATH CATH domains
2.60.120.260
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Galactose-binding domain-like
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3wf2 contains 8 copies of CATH domain 2.60.120.260 (Jelly Rolls) in Beta-galactosidase. Showing 2 copies in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Beta-galactosidase
The deposited structure of PDB entry 3wf2 contains 4 copies of CATH domain 3.20.20.80 (TIM Barrel) in Beta-galactosidase. Showing 1 copy in chain A.

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