Structure analysis

Crystal structure of TNFalpha in complex with Adalimumab Fab fragment

X-ray diffraction
3.101Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chain: A
Length: 157 amino acids
Theoretical weight: 17.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01375 (Residues: 77-233; Coverage: 67%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls

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Chain: H
Length: 219 amino acids
Theoretical weight: 23.27 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
InterPro:
CATH: Immunoglobulins

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