› 3wc7

X-ray diffraction
1.9Å resolution

Carboxypeptidase B in complex with EF6265

Released:
DOI: 10.2210/pdb3wc7/pdb
PDB entry 3wc7 coloured by chain, front view.
PDB entry 3wc7 coloured by chain, side view.
PDB entry 3wc7 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.
Yoshimoto N, Itoh T, Inaba Y, Ishii H, Yamamoto K
J Med Chem 56 7527-35 (2013)
PMID: 24010887

Function and Biology Details

Reaction catalysed: 
Preferential release of a C-terminal lysine or arginine amino acid.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase B Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.74 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P09955 (Residues: 111-416; Coverage: 76%)
Gene names: CPB, CPB1
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand EF1 1 x EF1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P41212
Unit cell:
a: 79.36Å b: 79.36Å c: 100.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.207

Quick links

Citations

1 review citation

Phosphinic Peptides as Tool Compounds for the Study of Pharmacologically Relevant Zn-Metalloproteases.
Georgiadis et al. (2022)
3 other articles