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Human alpha-l-iduronidase

Source organism: Homo sapiens
Biochemical function: hydrolase activity, hydrolyzing O-glycosyl compounds
Biological process: carbohydrate metabolic process
Cellular component: not assigned

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EC 3.2.1.76: L-iduronidase

Reaction catalysed:
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate
Systematic name:
Glycosaminoglycan alpha-L-iduronohydrolase
Alternative Name(s):
  • Alpha-L-iduronidase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF21200
Domain description: Alpha-L-iduronidase C-terminal domain
Occurring in:
  1. Alpha-L-iduronidase
The deposited structure of PDB entry 3w81 contains 2 copies of Pfam domain PF21200 (Alpha-L-iduronidase C-terminal domain) in Alpha-L-iduronidase. Showing 1 copy in chain A.

PF01229
Domain description: Glycosyl hydrolases family 39
Occurring in:
  1. Alpha-L-iduronidase
The deposited structure of PDB entry 3w81 contains 2 copies of Pfam domain PF01229 (Glycosyl hydrolases family 39) in Alpha-L-iduronidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000514
Domain description: Glycoside hydrolase, family 39
Occurring in:
  1. Alpha-L-iduronidase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Alpha-L-iduronidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Alpha-L-iduronidase

Structure domains

CATH CATH domains
2.60.40.1500
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Glycosyl hydrolase domain; family 39
Occurring in:
  1. Alpha-L-iduronidase
The deposited structure of PDB entry 3w81 contains 2 copies of CATH domain 2.60.40.1500 (Immunoglobulin-like) in Alpha-L-iduronidase. Showing 1 copy in chain A.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Alpha-L-iduronidase
The deposited structure of PDB entry 3w81 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Alpha-L-iduronidase. Showing 1 copy in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Alpha-L-iduronidase
The deposited structure of PDB entry 3w81 contains 2 copies of CATH domain 3.20.20.80 (TIM Barrel) in Alpha-L-iduronidase. Showing 1 copy in chain A.

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