› 3w16

X-ray diffraction
2.8Å resolution

Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III

Released:
DOI: 10.2210/pdb3w16/pdb
PDB entry 3w16 coloured by chain, front view.
PDB entry 3w16 coloured by chain, side view.
PDB entry 3w16 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Oliveira TM, Kairies NA, Engh RA

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 32.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 126-403; Coverage: 69%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand P9J 1 x P9J
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P6122
Unit cell:
a: 83.113Å b: 83.113Å c: 169.191Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.235 0.231 0.322
Expression system: Escherichia coli

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