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Crystal structure of human glutaminase in complex with inhibitor 4

X-ray diffraction
2.45Å resolution
PDB entry 3vp4 coloured by chain, front view.
PDB entry 3vp4 coloured by chain, side view.
PDB entry 3vp4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutaminase kidney isoform, mitochondrial 65 kDa chain
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Multimeric state: homo tetramer
Accessible surface area: 44767.08 Å2
Buried surface area: 6780.77 Å2
Dissociation area: 1,284.32 Å2
Dissociation energy (ΔGdiss): 4.66 kcal/mol
Dissociation entropy (TΔSdiss): 14.75 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131797

Macromolecules

Glutaminase kidney isoform, mitochondrial 65 kDa chain
Chain: A
Length: 316 amino acids
Theoretical weight: 34.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94925 (Residues: 221-533; Coverage: 47%)
Gene names: GLS, GLS1, KIAA0838
Pfam: Glutaminase
InterPro:
CATH: DD-peptidase/beta-lactamase superfamily
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 3vp4, assembly 1, front view.
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 3vp4, assembly 1, side view.
Glutaminase kidney isoform, mitochondrial 65 kDa chain in PDB entry 3vp4, assembly 1, top view.
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