› 3vke

X-ray diffraction
1.77Å resolution

Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides

Released:
DOI: 10.2210/pdb3vke/pdb
PDB entry 3vke coloured by chain, front view.
PDB entry 3vke coloured by chain, side view.
PDB entry 3vke coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides.
Yoga YM, Traore DA, Sidiqi M, Szeto C, Pendini NR, Barker A, Leedman PJ, Wilce JA, Wilce MC
Nucleic Acids Res 40 5101-14 (2012)
PMID: 22344691

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117059 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Poly(rC)-binding protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 76 amino acids
Theoretical weight: 8.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15365 (Residues: 14-86; Coverage: 21%)
Gene name: PCBP1
Sequence domains: KH domain
Structure domains: K Homology domain, type 1
DNA (5'-D(P*AP*CP*CP*CP*CP*A)-3') Chains: R, S, T, U
Molecule details ›
Chains: R, S, T, U
Length: 6 nucleotides
Theoretical weight: 1.74 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 38.597Å b: 114.887Å c: 43.429Å
α: 90° β: 93.73° γ: 90°
R-values:
R R work R free
0.164 0.161 0.213
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Non-canonical DNA structures: Diversity and disease association.
Bansal et al. (2022)
2 more

6 mentions without citation

The hnRNP family: insights into their role in health and disease.
Geuens et al. (2016)
5 more