› 3vdj

X-ray diffraction
1.7Å resolution

Crystal structure of circumsporozoite protein aTSR domain, R32 native form

Released:
DOI: 10.2210/pdb3vdj/pdb
PDB entry 3vdj coloured by chain, front view.
PDB entry 3vdj coloured by chain, side view.
PDB entry 3vdj coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Unexpected fold in the circumsporozoite protein target of malaria vaccines.
Doud MB, Koksal AC, Mi LZ, Song G, Lu C, Springer TA
Proc Natl Acad Sci U S A 109 7817-22 (2012)
PMID: 22547819

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-181562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Circumsporozoite protein Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.9 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: Q7K740 (Residues: 310-374; Coverage: 17%)
Gene names: CSP, PF3D7_0304600
Sequence domains: Thrombospondin type 1 domain
Structure domains: Thrombospondin type-1 (TSP1) repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: R32
Unit cell:
a: 66.515Å b: 66.515Å c: 85.506Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.17 0.2
Expression system: Komagataella phaffii GS115

Quick links

Citations

13 review citations

Antibodies against Plasmodium falciparum malaria at the molecular level.
Julien et al. (2019)
12 more

7 mentions without citation

Unexpected fold in the circumsporozoite protein target of malaria vaccines.
Doud et al. (2012)
6 more