PDBe 3v7a

X-ray diffraction
3.3Å resolution

Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Capsid protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 34.51 KDa
Source organism: Norovirus isolates
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5F4T5 (Residues: 224-538; Coverage: 58%)
Structure domains:
5B18 heavy chain Chains: E, F
Molecule details ›
Chains: E, F
Length: 223 amino acids
Theoretical weight: 23.71 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
5B18 kappa chain Chains: G, H
Molecule details ›
Chains: G, H
Length: 215 amino acids
Theoretical weight: 23.77 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P4322
Unit cell:
a: 145.48Å b: 145.48Å c: 216.334Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.227 0.283
Expression system: Escherichia coli